| 1 | Avengers: Endgame | 2019-04-24 | $356M | $918.37M | 2.58 |
| 2 | Spider-Man: No Way Home | 2021-12-15 | $200M | $864.8M | 4.32 |
| 3 | Black Panther | 2018-02-13 | $200M | $725.26M | 3.63 |
| 4 | Avengers: Infinity War | 2018-04-25 | $300M | $717.82M | 2.39 |
| 5 | Avatar: The Way of Water | 2022-12-14 | $350M | $705.81M | 2.02 |
| 6 | Jurassic World | 2015-06-06 | $150M | $670.7M | 4.47 |
| 7 | Avengers: Age of Ultron | 2015-04-22 | $365M | $483.6M | 1.32 |
| 8 | Black Panther: Wakanda Forever | 2022-11-09 | $250M | $481.83M | 1.93 |
| 9 | Captain Marvel | 2019-03-06 | $152M | $447.53M | 2.94 |
| 10 | Doctor Strange in the Multiverse of Madness | 2022-05-04 | $200M | $447.33M | 2.24 |
| 11 | Captain America: Civil War | 2016-04-27 | $250M | $433.08M | 1.73 |
| 12 | Jurassic World: Fallen Kingdom | 2018-06-06 | $170M | $432.07M | 2.54 |
| 13 | Wonder Woman | 2017-05-30 | $149M | $423.56M | 2.84 |
| 14 | Guardians of the Galaxy Vol. 2 | 2017-04-19 | $200M | $406.81M | 2.03 |
| 15 | Jumanji: Welcome to the Jungle | 2017-12-09 | $90M | $402.65M | 4.47 |
| 16 | Spider-Man: Across the Spider-Verse | 2023-05-31 | $100M | $398.94M | 3.99 |
| 17 | Jurassic World Dominion | 2022-06-01 | $165M | $394.01M | 2.39 |
| 18 | Spider-Man: Far From Home | 2019-06-28 | $160M | $391.36M | 2.45 |
| 19 | Superman | 2025-07-09 | $225M | $376.68M | 1.67 |
| 20 | Guardians of the Galaxy Vol. 3 | 2023-05-03 | $250M | $376.5M | 1.51 |
| 21 | Thor: Love and Thunder | 2022-07-06 | $250M | $372.26M | 1.49 |
| 22 | Batman v Superman: Dawn of Justice | 2016-03-23 | $250M | $358.06M | 1.43 |
| 23 | Spider-Man: Homecoming | 2017-07-05 | $175M | $349.97M | 2.00 |
| 24 | Suicide Squad | 2016-08-03 | $175M | $345.6M | 1.97 |
| 25 | Aquaman | 2018-12-07 | $160M | $344.06M | 2.15 |
| 26 | Jurassic World Rebirth | 2025-07-01 | $180M | $339.64M | 1.89 |
| 27 | Thor: Ragnarok | 2017-10-02 | $180M | $329.56M | 1.83 |
| 28 | Jumanji: The Next Level | 2019-12-04 | $125M | $321.53M | 2.57 |
| 29 | The Fantastic Four: First Steps | 2025-07-23 | $200M | $298.69M | 1.49 |
| 30 | The Hunger Games: Mockingjay - Part 2 | 2015-11-18 | $160M | $297.72M | 1.86 |
| 31 | Dune: Part Two | 2024-02-27 | $190M | $294.14M | 1.55 |
| 32 | Doctor Strange | 2016-10-25 | $180M | $242.04M | 1.34 |
| 33 | Justice League | 2017-11-15 | $300M | $242.02M | 0.81 |
| 34 | Logan | 2017-02-28 | $97M | $235.76M | 2.43 |
| 35 | Shang-Chi and the Legend of the Ten Rings | 2021-09-01 | $150M | $233.34M | 1.56 |
| 36 | Ant-Man and the Wasp: Quantumania | 2023-02-15 | $388M | $232.01M | 0.60 |
| 37 | Ant-Man and the Wasp | 2018-07-04 | $140M | $228.15M | 1.63 |
| 38 | Captain America: Brave New World | 2025-02-12 | $180M | $212.5M | 1.18 |
| 39 | Godzilla x Kong: The New Empire | 2024-03-27 | $150M | $206.35M | 1.38 |
| 40 | Thunderbolts* | 2025-04-30 | $180M | $201.77M | 1.12 |
| 41 | Spider-Man: Into the Spider-Verse | 2018-12-06 | $90M | $193.67M | 2.15 |
| 42 | Ant-Man | 2015-07-14 | $130M | $184.75M | 1.42 |
| 43 | F9 | 2021-05-19 | $200M | $180.11M | 0.90 |
| 44 | Fast & Furious Presents: Hobbs & Shaw | 2019-08-01 | $200M | $179.61M | 0.90 |
| 45 | Gladiator II | 2024-11-05 | $310M | $178.94M | 0.58 |
| 46 | Pirates of the Caribbean: Dead Men Tell No Tales | 2017-05-23 | $230M | $178.06M | 0.77 |
| 47 | Kingdom of the Planet of the Apes | 2024-05-08 | $160M | $177.73M | 1.11 |
| 48 | Black Adam | 2022-10-19 | $200M | $175.75M | 0.88 |
| 49 | Eternals | 2021-11-03 | $200M | $174.37M | 0.87 |
| 50 | Kong: Skull Island | 2017-03-08 | $185M | $171.75M | 0.93 |